This means genetic diseases such as haemophilia, muscular dystrophy and cancers, in principle, might be "corrected" by editing the DNA of human embryos.

Immune cells have an off switch that deactivates them before they can attack, which, in principle, is a good idea.

in principle), we would still have the other realm, where a lot of stuff would still be

One of our researchers had come up with a way to find a much, much more cost-effective way, in principle, of recycling a particular kind of polyester called PET.

Do you agree in principle with the famous Dieter Rahm's maxim, less but better?

We humans have an immense appetite for complicated things, neuroscience, astrophysics and molecular biology of course, but also barely decipherable books, abstract works of art and avant-garde pieces of theatre without plot or character, all of which perhaps evoke the primordial puzzles of the universe and our own always ineffable existence within it. But our veneration for complexity can reach a most painful, time-consuming and futile zenith in one area in particular – relationships. It's here that we find otherwise discerning and hard-headed people exhibiting extreme patience, often lasting over a succession of tormented years, for what we can call complicated situations. The complexities may arise from some of the following dynamics. A beloved partner who wants to commit and surely will one day but not quite yet on account of this or that factor or not entirely because of certain psychological fears or not conclusively or at least not without certain important caveats. They may need space, freedom or what they call a chance to explore though quite what was still not wholly clear, though we have asked them on many occasions. Then a partner with whom there are a lot of misunderstandings, around whom words often lose their standard meanings, around whom we may have to spend hours untangling what was truly meant and around whom gestures or deeds that we previously thought uncontentious suddenly become the occasion for major surprising aggravations. Or a partner who in principle is there for us and in theory loves us very very much but in actuality – like last week and the week before that – is constantly remarkably busy, unable to respond to our texts, out with their compelling friends or concentrated on their always extremely demanding job. Or a partner with whom we sit up late at night on many occasions with a pad and paper to hand attempting to determine where the issues are coming from, what is at play and how things might be handled before, baffled and upset, we finally have to retreat to bed a little after 1am feeling fragile and tearful.

Simple enough in principle, but soot builds up and it's tough on your back.

And so it was until Darwin came along and turned that upside down and realized that, in principle, there could be a process that would just inexorably grind out better and better and better designs and create the living world where there had been just lifeless matter before.

Based on the strength of Earth's gravity and the density and strength of rock, in principle you could make a single conical mountain that stretched between New York and Chicago and soared over 45 kilometers.

And then you have to scrap the whole thing because in principle the whole thing is about truth,